3M Emphaze AEX Hybrid Purifier Ref: EMP301AEX20R

The 3M Emphaze AEX Hybrid Purifier is a single-use clarification and purification capsule designed for biopharmaceutical and life science applications. It combines an anion-exchange (AEX) functional nonwoven media with a fine-particle bioburden reduction membrane, providing both mechanical and electrostatic contaminant removal in one step.

Key Features

• Model: EMP301AEX20R

• Type: Hybrid anion-exchange purifier capsule

• Construction: All-synthetic materials, Q-functional nonwoven + 0.2 µm-rated asymmetric membrane

• Operation Range: pH 5–9, temperature ≤40°C

• DNA Reduction: Greater than 4-log (10,000x) removal

• Host Cell Protein Reduction: 20–40% prior to Protein A chromatography

• Typical Effluent Turbidity: Less than 5 NTU

• Product Recovery: More than 95% for monoclonal antibodies

• Sanitizable/sterilizable model (indicated by “R” suffix)

• Single-use design reduces cleaning, validation, and downtime

Applications

• Clarification of cell culture harvests

• Removal of DNA, host cell proteins, and other impurities

• Pre-chromatography purification step in monoclonal antibody production

• Vaccine and recombinant protein process clarification

Benefits

• Combines clarification and purification into one unit operation

• Protects downstream chromatography columns and filters

• Improves process consistency and product purity

• Compact, single-use design for easy implementation in GMP settings

Additional Information

• Manufacturer: 3M

• Reference Number: EMP301AEX20R

• Condition: [Specify condition, e.g., “New in sealed packaging” or “Used and tested”]

• Ideal for: Biotech manufacturing, process development, and lab-scale purification