How Much Does an HPLC System Cost?

High-Performance Liquid Chromatography (HPLC) systems are foundational tools in analytical laboratories, widely used for compound separation, purity analysis, and quality control. But how much does an HPLC system cost? Prices vary widely based on system design, detector type, and whether the system is new or refurbished.

Key Takeaways

• Used HPLC systems start around $5,000

• New systems can exceed $80,000

• Detector choice strongly impacts price

• Refurbished systems offer the best ROI

• Modular upgrades help control costs

 

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Factors That Affect HPLC System Cost

System Configuration

A basic HPLC includes:

• Pump

• Autosampler

• Column compartment

• Detector

• Software

Each module adds to the total price.

Detector Type

• UV/Vis Detector: $5,000–$15,000

• DAD/PDA Detector: $8,000–$25,000

• Fluorescence Detector: $10,000–$30,000

• MS Detector: $50,000+

New vs. Refurbished

A new HPLC system can cost $40,000–$80,000, while refurbished systems often range from $8,000–$25,000.

Manufacturer

Common brands include Agilent, Waters, Shimadzu, and Thermo Fisher, with pricing influenced by model age and service availability.

 

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Benefits of HPLC Systems

• Reliable compound separation

• Essential for QC and compliance testing

• High reproducibility

• Broad application versatility

• Long operational lifespan

 

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Tips to Reduce HPLC Costs

• Buy refurbished modules individually

• Choose UV detection unless higher sensitivity is required

• Avoid unnecessary automation features

• Work with suppliers that offer testing and warranty

 

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HPLC Cost Summary

HPLC systems typically cost $5,000 to $80,000+, with refurbished systems providing excellent value for most labs.