Collection: Sonicators
Buy new, refurbished, and used sonicators from mLab Supply for research labs, pharmaceutical companies, universities, and biotechnology facilities. We source probe sonicators and ultrasonic processors for cell lysis, homogenization, sample disruption, and related laboratory workflows from leading manufacturers including Branson, Qsonica, Misonix, and Fisher Scientific. Net 30 available for qualified institutions. Browse available units below or request a quote for specific models and configurations. Our sourcing team can locate sonicators not currently listed — contact us for availability.
-
Fisher Scientific 505 Sonic Dismembrator — Request a Quote
Request Pricing
Épuisé -
Misonix S-4000 Ultrasonic Processor — Request a Quote
Request Pricing
Épuisé -
Qsonica Q700 Ultrasonic Processor — Request a Quote
Request Pricing
Épuisé -
Qsonica Q500 Ultrasonic Processor — Request a Quote
Request Pricing
Épuisé -
Branson SFX550 Probe Sonicator — Request a Quote
Request Pricing
Épuisé -
Branson SFX250 Probe Sonicator — Request a Quote
Request Pricing
Épuisé
<h2>How to Choose a Sonicator</h2>
<p>Selecting the right sonicator depends on your sample type, volume, and processing requirements. Key considerations include:</p>
<ul>
<li><strong>Sample volume:</strong> Sonicators are rated for specific volume ranges. Match the generator and probe to your typical processing volume — from microliters in microtubes to liters in larger vessels.</li>
<li><strong>Power requirements:</strong> Generator wattage determines the energy available for sonication. Higher-power units handle larger volumes and more demanding applications. Confirm the wattage range needed for your application before purchasing.</li>
<li><strong>Probe size and diameter:</strong> Larger-diameter probes deliver more energy to larger volumes. Smaller-diameter probes concentrate energy for small-volume or high-intensity applications. Probe diameter must be matched to sample volume and vessel size.</li>
<li><strong>Horn and probe compatibility:</strong> Confirm that replacement probes, horns, and boosters are compatible with the generator model. Probe thread patterns and booster configurations vary by manufacturer.</li>
<li><strong>Pulse control:</strong> Pulse mode alternates sonication on/off cycles to reduce heat buildup in temperature-sensitive samples. Confirm pulse control is available and adjustable on the unit.</li>
<li><strong>Amplitude control:</strong> Amplitude determines the intensity of probe vibration. Adjustable amplitude allows optimization for different sample types and volumes.</li>
<li><strong>Duty cycle:</strong> The ratio of on-time to off-time in pulse mode. Adjustable duty cycle is important for heat-sensitive samples.</li>
<li><strong>Cooling requirements:</strong> Sonication generates heat. Ice baths, cooling jackets, or chilled water circulation may be required for temperature-sensitive samples. Plan for cooling before purchase.</li>
<li><strong>Processing vessel:</strong> Confirm vessel compatibility — microtubes, conical tubes, beakers, and flow-through cells each require different probe configurations.</li>
<li><strong>Noise enclosure:</strong> Probe sonicators generate significant noise. Sound enclosures reduce operator exposure. Confirm enclosure availability and compatibility with your probe and stand configuration.</li>
<li><strong>Application type:</strong> Cell lysis, tissue disruption, nanoparticle dispersion, emulsification, and DNA shearing each have different energy and pulse requirements. Match the sonicator to your primary application.</li>
<li><strong>Throughput:</strong> For high-throughput applications, consider cup horn attachments or flow-through cells that allow continuous or batch processing without direct probe contact.</li>
</ul>
<h2>Sonicator Types</h2>
<h3>Probe Sonicators</h3>
<p>Probe sonicators use a metal probe (horn) that is immersed directly into the sample. Ultrasonic energy is transferred directly from the probe tip into the liquid, producing intense localized cavitation. Probe sonicators are the most common configuration for cell lysis, homogenization, and sample disruption in research laboratories. The Branson SFX250 and SFX550 are examples of probe sonicators in this collection.</p>
<h3>Ultrasonic Processors</h3>
<p>Ultrasonic processor is a commercial term used by several manufacturers — including Qsonica and Misonix — to describe their probe-based sonication systems. Functionally, ultrasonic processors operate on the same direct-contact probe principle as probe sonicators. The term reflects branding and product positioning rather than a fundamentally different operating principle. The Qsonica Q500, Q700, and Misonix S-4000 Ultrasonic Processor are examples in this collection.</p>
<h3>Sonic Dismembrators</h3>
<p>Sonic dismembrator is the term used by Fisher Scientific for their probe-based sonication instruments. The Fisher Scientific 505 Sonic Dismembrator operates on the same direct-contact probe principle as other probe sonicators and ultrasonic processors. The term is specific to Fisher Scientific's product line and does not indicate a different operating mechanism.</p>
<h2>Popular Sonicator Manufacturers and Models</h2>
<p>mLab Supply sources sonicators from leading manufacturers including Branson, Qsonica, Misonix, and Fisher Scientific. Common models available through our sourcing program include:</p>
<div class="mlab-collection-model-grid">
<h3>Branson</h3>
<ul>
<li>SFX250 Probe Sonicator</li>
<li>SFX550 Probe Sonicator</li>
</ul>
<h3>Qsonica</h3>
<ul>
<li>Q500 Ultrasonic Processor</li>
<li>Q700 Ultrasonic Processor</li>
</ul>
<h3>Misonix</h3>
<ul>
<li>S-4000 Ultrasonic Processor</li>
</ul>
<h3>Fisher Scientific</h3>
<ul>
<li>505 Sonic Dismembrator</li>
</ul>
</div>
<p>Model availability varies. <a href="/pages/request-a-quote">Request a quote</a> for current availability or to source a specific model not listed.</p>
<h2>Probe Sonicators vs. Ultrasonic Baths</h2>
<p>Probe sonicators and ultrasonic baths both use ultrasonic energy but differ significantly in how that energy is delivered:</p>
<ul>
<li><strong>Probe sonicators (direct-contact):</strong> The probe is immersed directly into the sample. Energy is transferred at high intensity directly from the probe tip into the liquid, producing intense localized cavitation. Probe sonicators are used for cell lysis, tissue disruption, homogenization, nanoparticle dispersion, emulsification, and other applications requiring concentrated, high-energy sonication. All instruments in this collection are probe-based systems.</li>
<li><strong>Ultrasonic baths (indirect sonication):</strong> The sample vessel is placed in a water bath that is sonicated from below. Energy is transferred indirectly through the water and vessel wall. Ultrasonic baths deliver lower, more distributed energy and are typically used for cleaning, degassing, and gentle mixing applications rather than cell disruption or homogenization.</li>
</ul>
<p>This collection covers probe sonicators and ultrasonic processors only. Ultrasonic baths and ultrasonic cleaners are a separate product category not represented here.</p>
<h2>Buying Used and Refurbished Sonicators</h2>
<p>Used and refurbished sonicators can provide significant cost savings. When evaluating a used unit, consider:</p>
<ul>
<li><strong>Generator condition:</strong> The generator converts electrical power to ultrasonic frequency. Confirm the generator powers on, reaches operating frequency, and does not exhibit error codes or instability.</li>
<li><strong>Probe and horn condition:</strong> Probes wear over time. Inspect the probe tip for erosion, pitting, or damage. Heavily worn probes deliver reduced energy and may need replacement.</li>
<li><strong>Transducer condition:</strong> The transducer converts electrical energy to mechanical vibration. Transducer issues can cause reduced output or failure to tune. Ask about transducer history where available.</li>
<li><strong>Cables and connectors:</strong> Inspect generator-to-transducer cables and connectors for damage or corrosion.</li>
<li><strong>Controller and display:</strong> Confirm the amplitude control, pulse settings, timer, and display are functional.</li>
<li><strong>Pulse and amplitude controls:</strong> Verify that pulse mode and amplitude adjustment operate correctly across the full range.</li>
<li><strong>Stand and clamp condition:</strong> Confirm the stand and probe clamp are included and functional. Stand configuration affects probe positioning and sample access.</li>
<li><strong>Included accessories:</strong> Probes, horns, stands, sound enclosures, and accessories vary by unit. Confirm what is included before purchase.</li>
<li><strong>Service history:</strong> Where available, service records provide useful context on maintenance and repairs.</li>
<li><strong>Sound enclosure availability:</strong> Confirm whether a sound enclosure is included or available for the specific model.</li>
<li><strong>Power requirements:</strong> Confirm voltage and amperage requirements match your facility before purchase.</li>
</ul>
<p>mLab Supply sources used and refurbished sonicators from research institutions, pharmaceutical companies, and surplus equipment programs. <a href="/pages/request-a-quote">Request a quote</a> for current availability.</p>
<h2>Probes, Horns, and Accessories</h2>
<p>Probe sonicator performance depends heavily on probe selection and accessory configuration. Key considerations:</p>
<ul>
<li><strong>Probe diameter:</strong> Larger-diameter probes deliver more energy to larger volumes. Smaller-diameter probes concentrate energy for small-volume or high-intensity applications. Match probe diameter to your sample volume and vessel.</li>
<li><strong>Tip condition:</strong> Probe tips erode with use. Inspect tip condition on used probes. Heavily eroded tips reduce energy delivery and may contaminate samples with metal particles.</li>
<li><strong>Replaceable tips:</strong> Some probe designs allow tip replacement without replacing the full probe body. Confirm tip replaceability for the specific probe model.</li>
<li><strong>Booster and horn compatibility:</strong> Boosters amplify or attenuate probe amplitude. Confirm booster and horn compatibility with the generator and probe before purchase.</li>
<li><strong>Stands and clamps:</strong> A stable stand and probe clamp are essential for consistent probe positioning. Confirm stand configuration and compatibility with your processing vessel.</li>
<li><strong>Sound enclosures:</strong> Sound enclosures significantly reduce operator noise exposure. Enclosure compatibility varies by probe and stand configuration. Confirm enclosure availability for the specific model.</li>
<li><strong>Vessel compatibility:</strong> Confirm that your processing vessels — microtubes, conical tubes, beakers, or flow-through cells — are compatible with the probe and stand configuration.</li>
</ul>
<p>Exact included accessories must be confirmed before purchase. Probes, horns, stands, enclosures, and accessories vary by unit. <a href="/pages/request-a-quote">Contact us</a> for details on a specific listing.</p>
<h2>Applications</h2>
<p>Probe sonicators and ultrasonic processors support a wide range of research and process-development workflows, including:</p>
<ul>
<li>Cell lysis for protein extraction, nucleic acid isolation, and other downstream applications</li>
<li>Tissue disruption and homogenization</li>
<li>Nanoparticle dispersion and deagglomeration</li>
<li>Emulsification of immiscible liquids</li>
<li>Sample preparation for analytical workflows</li>
<li>DNA and chromatin shearing for sequencing and ChIP applications where appropriate</li>
<li>Deagglomeration of particle suspensions</li>
<li>Research and process-development workflows requiring controlled ultrasonic energy delivery</li>
</ul>
<p>Claims about suitability for specific regulated applications depend on buyer qualification, validation, SOPs, documentation, quality-system requirements, and intended use. Buyers are responsible for confirming that any instrument meets their specific application requirements.</p>
<h2>Sonicators vs. Homogenizers</h2>
<p>Sonicators and homogenizers both disrupt biological samples and reduce particle size, but they use different mechanisms:</p>
<ul>
<li><strong>Sonicators:</strong> Use ultrasonic energy delivered through a vibrating probe to generate cavitation in the sample. Cavitation produces intense localized pressure waves that disrupt cells and particles. Probe sonicators are well-suited for liquid samples in tubes or vessels.</li>
<li><strong>Mechanical homogenizers:</strong> Use physical mixing methods including rotor-stator, bead-based (bead mill), or other mechanical disruption approaches. Rotor-stator homogenizers use a high-speed rotating blade within a stator to shear samples. Bead mills use agitated beads to disrupt cells and tissues. Mechanical homogenizers are often preferred for viscous samples, tissue homogenization, or applications where ultrasonic energy is not appropriate.</li>
</ul>
<p>See our <a href="/collections/homogenizers-and-bead-mills">Homogenizers & Bead Mills</a> collection for mechanical disruption instruments.</p>
<h2>Procurement and Logistics Support</h2>
<p>mLab Supply supports institutional and commercial laboratory equipment procurement. Our team can assist with:</p>
<ul>
<li><strong>Formal quotations:</strong> Written quotes for institutional purchasing, vendor onboarding, and purchase order workflows.</li>
<li><strong>Sourcing specific models:</strong> If a specific sonicator model or configuration is not currently listed, contact us. We can often source it through our supplier network.</li>
<li><strong>Configuration checks:</strong> We can advise on probe, horn, and accessory compatibility for specific models before purchase.</li>
<li><strong>Shipping coordination:</strong> We coordinate shipping logistics for qualified orders, including packaging requirements for sensitive instruments.</li>
<li><strong>Availability requests:</strong> Contact us to request availability on specific models or configurations not currently listed.</li>
</ul>
<p><a href="/pages/request-a-quote">Request a quote</a> or contact us to discuss your procurement requirements.</p>
<h2>Related Laboratory Equipment</h2>
<p>Buyers sourcing sonicators often also need complementary sample preparation and processing instruments. mLab Supply sources a broad range of laboratory instruments, including <a href="/collections/homogenizers-and-bead-mills">Homogenizers & Bead Mills</a> for mechanical disruption workflows and <a href="/collections/centrifuges">Centrifuges</a> for downstream sample processing. Browse our full <a href="/collections/labequipment">Lab Equipment</a> catalog. To <a href="/pages/sell-lab-equipment">sell surplus laboratory equipment</a>, we purchase used instruments from institutions and research facilities.</p>
<h2>Why Buy From mLab Supply?</h2>
<ul>
<li>New, refurbished, and surplus sonicators sourced from research institutions and commercial facilities</li>
<li>Ability to source discontinued and hard-to-find models through our supplier network</li>
<li>Vendor and procurement support for institutional purchasing workflows</li>
<li>Net 30 available for qualified institutions</li>
<li>Nationwide shipping coordination</li>
<li>Equipment purchasing and trade-in programs for surplus sonicators</li>
<li>Configuration and compatibility guidance on probes, horns, and accessories</li>
</ul>
<div class="mlab-collection-faq">
<h2>Frequently Asked Questions</h2>
<details>
<summary>What is a sonicator?</summary>
<p>A sonicator is a laboratory instrument that uses ultrasonic energy to disrupt, homogenize, or process samples. Probe sonicators deliver ultrasonic energy through a vibrating metal probe immersed directly in the sample, generating cavitation that disrupts cells, particles, and emulsions. They are widely used for cell lysis, tissue disruption, nanoparticle dispersion, and sample preparation in research and process-development workflows.</p>
</details>
<details>
<summary>What is the difference between a probe sonicator and an ultrasonic bath?</summary>
<p>Probe sonicators deliver ultrasonic energy directly into the sample through an immersed probe, producing intense localized cavitation. They are used for cell lysis, homogenization, and sample disruption. Ultrasonic baths deliver energy indirectly through a water bath, producing lower, more distributed energy suitable for cleaning, degassing, and gentle mixing. All instruments in this collection are probe-based systems. Ultrasonic baths are a separate product category.</p>
</details>
<details>
<summary>What probe size do I need?</summary>
<p>Probe size depends on your sample volume and vessel. Larger-diameter probes deliver more energy to larger volumes. Smaller-diameter probes concentrate energy for small-volume or high-intensity applications such as microtubes. Consult the manufacturer's probe selection guide for the specific generator model. <a href="/pages/request-a-quote">Contact us</a> to discuss probe compatibility for a specific unit.</p>
</details>
<details>
<summary>What power level should I choose?</summary>
<p>Generator wattage determines the energy available for sonication. Higher-power units handle larger volumes and more demanding applications. Match generator wattage to your typical sample volume and application. For most research cell lysis and homogenization applications, 250–750W generators cover a broad range of volumes. <a href="/pages/request-a-quote">Contact us</a> to discuss power requirements for your application.</p>
</details>
<details>
<summary>Are probes and horns included with used sonicators?</summary>
<p>Included probes, horns, stands, sound enclosures, and accessories vary by unit. Some used sonicators are sold with a full complement of original accessories; others may have partial or no accessories. Confirm what is included with any specific unit before purchase. <a href="/pages/request-a-quote">Contact us</a> for details on a specific listing.</p>
</details>
<details>
<summary>What should I inspect before buying a used sonicator?</summary>
<p>Key inspection points include generator condition and output stability, probe tip condition (erosion and pitting), transducer history, cable and connector integrity, controller and display function, pulse and amplitude control operation, stand and clamp condition, and included accessories. Service history where available provides additional context.</p>
</details>
<details>
<summary>Can mLab Supply source a specific Branson, Qsonica, Misonix, or Fisher Scientific sonicator?</summary>
<p>Yes. If a specific model is not currently listed, our sourcing team can often locate it through our supplier and institutional network. <a href="/pages/request-a-quote">Submit a quote request</a> with the model number and your requirements and we will follow up on availability.</p>
</details>
<details>
<summary>Are refurbished sonicators suitable for regulated laboratory applications?</summary>
<p>Suitability for regulated applications including GMP manufacturing, clinical diagnostics, or pharmaceutical processing depends on buyer qualification, validation, SOPs, documentation, quality-system requirements, and intended use. mLab Supply does not guarantee that any unit meets specific regulatory requirements. Buyers are responsible for confirming suitability for their application.</p>
</details>
<details>
<summary>Does mLab Supply coordinate shipping for sonicators?</summary>
<p>Yes. We coordinate shipping logistics for qualified orders, including appropriate packaging for sensitive instruments. <a href="/pages/request-a-quote">Contact us</a> to discuss shipping requirements for your order.</p>
</details>
<details>
<summary>Does mLab Supply purchase surplus sonicators?</summary>
<p>Yes. We purchase used and surplus sonicators from research institutions, pharmaceutical companies, and commercial facilities. Visit our <a href="/pages/sell-lab-equipment">Sell Lab Equipment</a> page to submit details about your surplus equipment.</p>
</details>
<details>
<summary>Does mLab Supply offer Net 30 terms?</summary>
<p>Net 30 payment terms are available for qualified institutions. <a href="/pages/request-a-quote">Contact us</a> to discuss payment terms for your organization.</p>
</details>
</div>
<p>Selecting the right sonicator depends on your sample type, volume, and processing requirements. Key considerations include:</p>
<ul>
<li><strong>Sample volume:</strong> Sonicators are rated for specific volume ranges. Match the generator and probe to your typical processing volume — from microliters in microtubes to liters in larger vessels.</li>
<li><strong>Power requirements:</strong> Generator wattage determines the energy available for sonication. Higher-power units handle larger volumes and more demanding applications. Confirm the wattage range needed for your application before purchasing.</li>
<li><strong>Probe size and diameter:</strong> Larger-diameter probes deliver more energy to larger volumes. Smaller-diameter probes concentrate energy for small-volume or high-intensity applications. Probe diameter must be matched to sample volume and vessel size.</li>
<li><strong>Horn and probe compatibility:</strong> Confirm that replacement probes, horns, and boosters are compatible with the generator model. Probe thread patterns and booster configurations vary by manufacturer.</li>
<li><strong>Pulse control:</strong> Pulse mode alternates sonication on/off cycles to reduce heat buildup in temperature-sensitive samples. Confirm pulse control is available and adjustable on the unit.</li>
<li><strong>Amplitude control:</strong> Amplitude determines the intensity of probe vibration. Adjustable amplitude allows optimization for different sample types and volumes.</li>
<li><strong>Duty cycle:</strong> The ratio of on-time to off-time in pulse mode. Adjustable duty cycle is important for heat-sensitive samples.</li>
<li><strong>Cooling requirements:</strong> Sonication generates heat. Ice baths, cooling jackets, or chilled water circulation may be required for temperature-sensitive samples. Plan for cooling before purchase.</li>
<li><strong>Processing vessel:</strong> Confirm vessel compatibility — microtubes, conical tubes, beakers, and flow-through cells each require different probe configurations.</li>
<li><strong>Noise enclosure:</strong> Probe sonicators generate significant noise. Sound enclosures reduce operator exposure. Confirm enclosure availability and compatibility with your probe and stand configuration.</li>
<li><strong>Application type:</strong> Cell lysis, tissue disruption, nanoparticle dispersion, emulsification, and DNA shearing each have different energy and pulse requirements. Match the sonicator to your primary application.</li>
<li><strong>Throughput:</strong> For high-throughput applications, consider cup horn attachments or flow-through cells that allow continuous or batch processing without direct probe contact.</li>
</ul>
<h2>Sonicator Types</h2>
<h3>Probe Sonicators</h3>
<p>Probe sonicators use a metal probe (horn) that is immersed directly into the sample. Ultrasonic energy is transferred directly from the probe tip into the liquid, producing intense localized cavitation. Probe sonicators are the most common configuration for cell lysis, homogenization, and sample disruption in research laboratories. The Branson SFX250 and SFX550 are examples of probe sonicators in this collection.</p>
<h3>Ultrasonic Processors</h3>
<p>Ultrasonic processor is a commercial term used by several manufacturers — including Qsonica and Misonix — to describe their probe-based sonication systems. Functionally, ultrasonic processors operate on the same direct-contact probe principle as probe sonicators. The term reflects branding and product positioning rather than a fundamentally different operating principle. The Qsonica Q500, Q700, and Misonix S-4000 Ultrasonic Processor are examples in this collection.</p>
<h3>Sonic Dismembrators</h3>
<p>Sonic dismembrator is the term used by Fisher Scientific for their probe-based sonication instruments. The Fisher Scientific 505 Sonic Dismembrator operates on the same direct-contact probe principle as other probe sonicators and ultrasonic processors. The term is specific to Fisher Scientific's product line and does not indicate a different operating mechanism.</p>
<h2>Popular Sonicator Manufacturers and Models</h2>
<p>mLab Supply sources sonicators from leading manufacturers including Branson, Qsonica, Misonix, and Fisher Scientific. Common models available through our sourcing program include:</p>
<div class="mlab-collection-model-grid">
<h3>Branson</h3>
<ul>
<li>SFX250 Probe Sonicator</li>
<li>SFX550 Probe Sonicator</li>
</ul>
<h3>Qsonica</h3>
<ul>
<li>Q500 Ultrasonic Processor</li>
<li>Q700 Ultrasonic Processor</li>
</ul>
<h3>Misonix</h3>
<ul>
<li>S-4000 Ultrasonic Processor</li>
</ul>
<h3>Fisher Scientific</h3>
<ul>
<li>505 Sonic Dismembrator</li>
</ul>
</div>
<p>Model availability varies. <a href="/pages/request-a-quote">Request a quote</a> for current availability or to source a specific model not listed.</p>
<h2>Probe Sonicators vs. Ultrasonic Baths</h2>
<p>Probe sonicators and ultrasonic baths both use ultrasonic energy but differ significantly in how that energy is delivered:</p>
<ul>
<li><strong>Probe sonicators (direct-contact):</strong> The probe is immersed directly into the sample. Energy is transferred at high intensity directly from the probe tip into the liquid, producing intense localized cavitation. Probe sonicators are used for cell lysis, tissue disruption, homogenization, nanoparticle dispersion, emulsification, and other applications requiring concentrated, high-energy sonication. All instruments in this collection are probe-based systems.</li>
<li><strong>Ultrasonic baths (indirect sonication):</strong> The sample vessel is placed in a water bath that is sonicated from below. Energy is transferred indirectly through the water and vessel wall. Ultrasonic baths deliver lower, more distributed energy and are typically used for cleaning, degassing, and gentle mixing applications rather than cell disruption or homogenization.</li>
</ul>
<p>This collection covers probe sonicators and ultrasonic processors only. Ultrasonic baths and ultrasonic cleaners are a separate product category not represented here.</p>
<h2>Buying Used and Refurbished Sonicators</h2>
<p>Used and refurbished sonicators can provide significant cost savings. When evaluating a used unit, consider:</p>
<ul>
<li><strong>Generator condition:</strong> The generator converts electrical power to ultrasonic frequency. Confirm the generator powers on, reaches operating frequency, and does not exhibit error codes or instability.</li>
<li><strong>Probe and horn condition:</strong> Probes wear over time. Inspect the probe tip for erosion, pitting, or damage. Heavily worn probes deliver reduced energy and may need replacement.</li>
<li><strong>Transducer condition:</strong> The transducer converts electrical energy to mechanical vibration. Transducer issues can cause reduced output or failure to tune. Ask about transducer history where available.</li>
<li><strong>Cables and connectors:</strong> Inspect generator-to-transducer cables and connectors for damage or corrosion.</li>
<li><strong>Controller and display:</strong> Confirm the amplitude control, pulse settings, timer, and display are functional.</li>
<li><strong>Pulse and amplitude controls:</strong> Verify that pulse mode and amplitude adjustment operate correctly across the full range.</li>
<li><strong>Stand and clamp condition:</strong> Confirm the stand and probe clamp are included and functional. Stand configuration affects probe positioning and sample access.</li>
<li><strong>Included accessories:</strong> Probes, horns, stands, sound enclosures, and accessories vary by unit. Confirm what is included before purchase.</li>
<li><strong>Service history:</strong> Where available, service records provide useful context on maintenance and repairs.</li>
<li><strong>Sound enclosure availability:</strong> Confirm whether a sound enclosure is included or available for the specific model.</li>
<li><strong>Power requirements:</strong> Confirm voltage and amperage requirements match your facility before purchase.</li>
</ul>
<p>mLab Supply sources used and refurbished sonicators from research institutions, pharmaceutical companies, and surplus equipment programs. <a href="/pages/request-a-quote">Request a quote</a> for current availability.</p>
<h2>Probes, Horns, and Accessories</h2>
<p>Probe sonicator performance depends heavily on probe selection and accessory configuration. Key considerations:</p>
<ul>
<li><strong>Probe diameter:</strong> Larger-diameter probes deliver more energy to larger volumes. Smaller-diameter probes concentrate energy for small-volume or high-intensity applications. Match probe diameter to your sample volume and vessel.</li>
<li><strong>Tip condition:</strong> Probe tips erode with use. Inspect tip condition on used probes. Heavily eroded tips reduce energy delivery and may contaminate samples with metal particles.</li>
<li><strong>Replaceable tips:</strong> Some probe designs allow tip replacement without replacing the full probe body. Confirm tip replaceability for the specific probe model.</li>
<li><strong>Booster and horn compatibility:</strong> Boosters amplify or attenuate probe amplitude. Confirm booster and horn compatibility with the generator and probe before purchase.</li>
<li><strong>Stands and clamps:</strong> A stable stand and probe clamp are essential for consistent probe positioning. Confirm stand configuration and compatibility with your processing vessel.</li>
<li><strong>Sound enclosures:</strong> Sound enclosures significantly reduce operator noise exposure. Enclosure compatibility varies by probe and stand configuration. Confirm enclosure availability for the specific model.</li>
<li><strong>Vessel compatibility:</strong> Confirm that your processing vessels — microtubes, conical tubes, beakers, or flow-through cells — are compatible with the probe and stand configuration.</li>
</ul>
<p>Exact included accessories must be confirmed before purchase. Probes, horns, stands, enclosures, and accessories vary by unit. <a href="/pages/request-a-quote">Contact us</a> for details on a specific listing.</p>
<h2>Applications</h2>
<p>Probe sonicators and ultrasonic processors support a wide range of research and process-development workflows, including:</p>
<ul>
<li>Cell lysis for protein extraction, nucleic acid isolation, and other downstream applications</li>
<li>Tissue disruption and homogenization</li>
<li>Nanoparticle dispersion and deagglomeration</li>
<li>Emulsification of immiscible liquids</li>
<li>Sample preparation for analytical workflows</li>
<li>DNA and chromatin shearing for sequencing and ChIP applications where appropriate</li>
<li>Deagglomeration of particle suspensions</li>
<li>Research and process-development workflows requiring controlled ultrasonic energy delivery</li>
</ul>
<p>Claims about suitability for specific regulated applications depend on buyer qualification, validation, SOPs, documentation, quality-system requirements, and intended use. Buyers are responsible for confirming that any instrument meets their specific application requirements.</p>
<h2>Sonicators vs. Homogenizers</h2>
<p>Sonicators and homogenizers both disrupt biological samples and reduce particle size, but they use different mechanisms:</p>
<ul>
<li><strong>Sonicators:</strong> Use ultrasonic energy delivered through a vibrating probe to generate cavitation in the sample. Cavitation produces intense localized pressure waves that disrupt cells and particles. Probe sonicators are well-suited for liquid samples in tubes or vessels.</li>
<li><strong>Mechanical homogenizers:</strong> Use physical mixing methods including rotor-stator, bead-based (bead mill), or other mechanical disruption approaches. Rotor-stator homogenizers use a high-speed rotating blade within a stator to shear samples. Bead mills use agitated beads to disrupt cells and tissues. Mechanical homogenizers are often preferred for viscous samples, tissue homogenization, or applications where ultrasonic energy is not appropriate.</li>
</ul>
<p>See our <a href="/collections/homogenizers-and-bead-mills">Homogenizers & Bead Mills</a> collection for mechanical disruption instruments.</p>
<h2>Procurement and Logistics Support</h2>
<p>mLab Supply supports institutional and commercial laboratory equipment procurement. Our team can assist with:</p>
<ul>
<li><strong>Formal quotations:</strong> Written quotes for institutional purchasing, vendor onboarding, and purchase order workflows.</li>
<li><strong>Sourcing specific models:</strong> If a specific sonicator model or configuration is not currently listed, contact us. We can often source it through our supplier network.</li>
<li><strong>Configuration checks:</strong> We can advise on probe, horn, and accessory compatibility for specific models before purchase.</li>
<li><strong>Shipping coordination:</strong> We coordinate shipping logistics for qualified orders, including packaging requirements for sensitive instruments.</li>
<li><strong>Availability requests:</strong> Contact us to request availability on specific models or configurations not currently listed.</li>
</ul>
<p><a href="/pages/request-a-quote">Request a quote</a> or contact us to discuss your procurement requirements.</p>
<h2>Related Laboratory Equipment</h2>
<p>Buyers sourcing sonicators often also need complementary sample preparation and processing instruments. mLab Supply sources a broad range of laboratory instruments, including <a href="/collections/homogenizers-and-bead-mills">Homogenizers & Bead Mills</a> for mechanical disruption workflows and <a href="/collections/centrifuges">Centrifuges</a> for downstream sample processing. Browse our full <a href="/collections/labequipment">Lab Equipment</a> catalog. To <a href="/pages/sell-lab-equipment">sell surplus laboratory equipment</a>, we purchase used instruments from institutions and research facilities.</p>
<h2>Why Buy From mLab Supply?</h2>
<ul>
<li>New, refurbished, and surplus sonicators sourced from research institutions and commercial facilities</li>
<li>Ability to source discontinued and hard-to-find models through our supplier network</li>
<li>Vendor and procurement support for institutional purchasing workflows</li>
<li>Net 30 available for qualified institutions</li>
<li>Nationwide shipping coordination</li>
<li>Equipment purchasing and trade-in programs for surplus sonicators</li>
<li>Configuration and compatibility guidance on probes, horns, and accessories</li>
</ul>
<div class="mlab-collection-faq">
<h2>Frequently Asked Questions</h2>
<details>
<summary>What is a sonicator?</summary>
<p>A sonicator is a laboratory instrument that uses ultrasonic energy to disrupt, homogenize, or process samples. Probe sonicators deliver ultrasonic energy through a vibrating metal probe immersed directly in the sample, generating cavitation that disrupts cells, particles, and emulsions. They are widely used for cell lysis, tissue disruption, nanoparticle dispersion, and sample preparation in research and process-development workflows.</p>
</details>
<details>
<summary>What is the difference between a probe sonicator and an ultrasonic bath?</summary>
<p>Probe sonicators deliver ultrasonic energy directly into the sample through an immersed probe, producing intense localized cavitation. They are used for cell lysis, homogenization, and sample disruption. Ultrasonic baths deliver energy indirectly through a water bath, producing lower, more distributed energy suitable for cleaning, degassing, and gentle mixing. All instruments in this collection are probe-based systems. Ultrasonic baths are a separate product category.</p>
</details>
<details>
<summary>What probe size do I need?</summary>
<p>Probe size depends on your sample volume and vessel. Larger-diameter probes deliver more energy to larger volumes. Smaller-diameter probes concentrate energy for small-volume or high-intensity applications such as microtubes. Consult the manufacturer's probe selection guide for the specific generator model. <a href="/pages/request-a-quote">Contact us</a> to discuss probe compatibility for a specific unit.</p>
</details>
<details>
<summary>What power level should I choose?</summary>
<p>Generator wattage determines the energy available for sonication. Higher-power units handle larger volumes and more demanding applications. Match generator wattage to your typical sample volume and application. For most research cell lysis and homogenization applications, 250–750W generators cover a broad range of volumes. <a href="/pages/request-a-quote">Contact us</a> to discuss power requirements for your application.</p>
</details>
<details>
<summary>Are probes and horns included with used sonicators?</summary>
<p>Included probes, horns, stands, sound enclosures, and accessories vary by unit. Some used sonicators are sold with a full complement of original accessories; others may have partial or no accessories. Confirm what is included with any specific unit before purchase. <a href="/pages/request-a-quote">Contact us</a> for details on a specific listing.</p>
</details>
<details>
<summary>What should I inspect before buying a used sonicator?</summary>
<p>Key inspection points include generator condition and output stability, probe tip condition (erosion and pitting), transducer history, cable and connector integrity, controller and display function, pulse and amplitude control operation, stand and clamp condition, and included accessories. Service history where available provides additional context.</p>
</details>
<details>
<summary>Can mLab Supply source a specific Branson, Qsonica, Misonix, or Fisher Scientific sonicator?</summary>
<p>Yes. If a specific model is not currently listed, our sourcing team can often locate it through our supplier and institutional network. <a href="/pages/request-a-quote">Submit a quote request</a> with the model number and your requirements and we will follow up on availability.</p>
</details>
<details>
<summary>Are refurbished sonicators suitable for regulated laboratory applications?</summary>
<p>Suitability for regulated applications including GMP manufacturing, clinical diagnostics, or pharmaceutical processing depends on buyer qualification, validation, SOPs, documentation, quality-system requirements, and intended use. mLab Supply does not guarantee that any unit meets specific regulatory requirements. Buyers are responsible for confirming suitability for their application.</p>
</details>
<details>
<summary>Does mLab Supply coordinate shipping for sonicators?</summary>
<p>Yes. We coordinate shipping logistics for qualified orders, including appropriate packaging for sensitive instruments. <a href="/pages/request-a-quote">Contact us</a> to discuss shipping requirements for your order.</p>
</details>
<details>
<summary>Does mLab Supply purchase surplus sonicators?</summary>
<p>Yes. We purchase used and surplus sonicators from research institutions, pharmaceutical companies, and commercial facilities. Visit our <a href="/pages/sell-lab-equipment">Sell Lab Equipment</a> page to submit details about your surplus equipment.</p>
</details>
<details>
<summary>Does mLab Supply offer Net 30 terms?</summary>
<p>Net 30 payment terms are available for qualified institutions. <a href="/pages/request-a-quote">Contact us</a> to discuss payment terms for your organization.</p>
</details>
</div>