Collection: Automated Liquid Handlers
Automated Liquid Handlers for Sale
Buy used, refurbished, and available-to-source automated liquid handlers from mLab Supply. We source benchtop and full-deck liquid handling workstations for genomics, drug discovery, ELISA, NGS library preparation, and high-throughput sample prep workflows. Represented platforms include Beckman Coulter Biomek and Echo systems, Hamilton Microlab STAR, Tecan Freedom EVO, Eppendorf epMotion, and Agilent Bravo. All systems are quote-based — submit a request and we will confirm availability, configuration, and lead time within 1–2 business days.
## How to Choose an Automated Liquid Handler
Selecting the right liquid handling workstation depends on your workflow requirements, throughput targets, and laboratory infrastructure. Key factors to evaluate:
**Throughput and run volume.** Estimate your daily plate output and whether you need unattended overnight operation. High-throughput screening labs typically require 96- or 384-channel heads and integrated plate hotels, while lower-throughput genomics workflows may be well served by an 8-channel or span-8 system.
**Deck capacity.** Count the number of deck positions required for tips, reagent reservoirs, labware carriers, and integrated instruments. Larger decks support more complex workflows but require more bench space.
**Pipetting volume range.** Confirm the minimum and maximum aspiration volumes for your assay. NGS library prep and low-volume compound handling require accurate sub-microliter dispensing; ELISA and normalization workflows typically operate in the 10–200 µL range.
**Channel count and head configuration.** Single-channel, 8-channel, 96-channel, and span-8 heads each offer different throughput and flexibility trade-offs. Some platforms support interchangeable heads.
**Disposable tips vs. fixed tips.** Disposable tip systems reduce cross-contamination risk and are standard for most life science workflows. Fixed-tip systems (common in acoustic and some positive-displacement platforms) require wash steps between transfers.
**Labware compatibility.** Verify that the system supports your plate formats, tube types, and reservoir configurations. Confirm tip compatibility with your preferred tip vendor.
**Grippers and plate movement.** Integrated gripper arms allow automated plate transport between deck positions and integrated instruments. Confirm gripper reach and compatibility with your labware stack heights.
**Onboard accessories.** Barcode readers, tip counters, liquid-level sensing, and integrated shakers or heating/cooling modules vary by platform and configuration.
**Scheduling software and integration.** Evaluate the method development environment, scripting complexity, and compatibility with your LIMS, scheduling software, and any integrated instruments such as plate readers, centrifuges, or sealers.
**Footprint and serviceability.** Confirm bench dimensions and weight capacity. Consider local service availability and spare parts access for the platform you select.
---
## Automated Liquid Handler Types
### Air-Displacement Pipetting Workstations
Air-displacement systems are the most common platform in life science laboratories. They use a sealed air column to aspirate and dispense liquid, with disposable tips to prevent cross-contamination. Platforms such as the Beckman Coulter Biomek series, Hamilton Microlab STAR, Tecan Freedom EVO, and Eppendorf epMotion use air-displacement pipetting. These systems are well suited for genomics, proteomics, ELISA, normalization, and general sample preparation.
### Positive-Displacement / Specialized Pipetting
Positive-displacement systems use a piston in direct contact with the liquid, making them suitable for viscous, volatile, or high-density samples where air-displacement accuracy is compromised. Some platforms offer positive-displacement heads as optional accessories.
### Acoustic Liquid Handling
Acoustic liquid handlers use focused sound energy to transfer nanoliter-to-microliter volumes without tips, eliminating tip costs and cross-contamination risk. The Beckman Coulter Echo 525 and Echo 650 are acoustic platforms commonly used for compound management, assay miniaturization, and DMSO-based transfers. Acoustic systems are not suitable for all liquid types and require compatible source plate formats.
### Integrated Robotic Workstations
Some liquid handling platforms are designed as the central component of a larger robotic workcell, with robotic arms, plate hotels, incubators, readers, and sealers integrated around a central scheduler. The Hamilton STAR and Tecan Freedom EVO are frequently configured as workcell hubs. These systems offer the highest throughput and automation depth but require more complex method development and infrastructure.
---
## Popular Manufacturers and Platforms
<div class="mlab-collection-model-grid">
**Beckman Coulter**
- Biomek FXᴾ — Full-deck, 96/384-channel capable workstation for high-throughput genomics and screening
- Biomek NXᴾ — Flexible benchtop platform with span-8 and 96-channel head options
- Biomek 4000 — Mid-range workstation with modular deck and multi-channel pipetting
- Biomek i3 — Compact intelligent workstation for routine sample prep
- Biomek i5 — Mid-range intelligent workstation with expanded deck capacity
- Biomek i7 — High-capacity intelligent workstation for complex, high-throughput workflows
- Echo 525 — Acoustic liquid handler for nanoliter compound and assay transfers
- Echo 650 — Higher-throughput acoustic platform with expanded source plate capacity
**Hamilton**
- Microlab STAR — Modular, high-precision workstation widely used in genomics, NGS prep, and clinical automation
**Tecan**
- Freedom EVO — Configurable workcell platform with broad labware and integration support
- Freedom EVO 150 — Compact EVO variant with 150 mm deck width for space-constrained environments
**Eppendorf**
- epMotion 5075 — Compact benchtop liquid handler for PCR setup, normalization, and routine sample prep
**Agilent Technologies**
- Bravo — Plate-based liquid handling platform commonly used for NGS library prep and compound reformatting
</div>
---
## Automated Liquid Handlers vs Manual Pipetting
Automated liquid handlers and manual pipetting each have a role in laboratory workflows. The right choice depends on throughput, reproducibility requirements, budget, and assay complexity.
**Throughput.** Manual pipetting is practical for low-volume, low-frequency tasks. Automated systems become cost-effective when processing dozens to hundreds of plates per week, or when run frequency justifies the capital investment.
**Reproducibility.** Automated systems eliminate operator-to-operator variability in pipetting volume, timing, and technique. This is particularly important for quantitative assays, NGS library preparation, and regulated workflows where inter-operator variability must be controlled.
**Operator variability and ergonomics.** Repetitive manual pipetting carries ergonomic risk. Automation reduces operator fatigue and the associated variability in high-volume workflows.
**Method setup.** Automated systems require upfront method development and validation. Simple workflows can be programmed quickly on most platforms; complex multi-step protocols require more development time.
**Flexibility.** Manual pipetting is more flexible for ad hoc, low-volume, or highly variable tasks. Automated systems are optimized for defined, repeatable workflows.
**Capital cost.** Automated liquid handlers represent a significant capital investment. Used and refurbished systems can substantially reduce acquisition cost while delivering the same workflow capability.
**Validation burden.** Regulated laboratories (GMP, GLP, CAP, CLIA) must validate automated liquid handling systems before use. Validation requirements vary by regulatory framework and intended use.
---
## Buying Used and Refurbished Liquid Handlers
Used and refurbished automated liquid handlers can deliver significant cost savings compared to new systems. When evaluating a pre-owned system, consider the following:
**Pipetting head condition.** Inspect or request documentation on pipetting accuracy and precision. Tip eject function, seal integrity, and piston condition affect pipetting performance.
**Deck alignment.** Confirm that deck positions are correctly calibrated and that labware carriers seat properly. Misalignment can cause tip pickup failures and liquid transfer errors.
**Liquid-level sensing.** Many platforms include capacitive or pressure-based liquid-level sensing. Confirm that sensing hardware is present and functional if required for your workflow.
**Tip compatibility.** Verify that the system is compatible with your preferred tip vendor and that tip adapters or racks are included or available.
**Gripper function.** If the system includes a gripper arm, confirm range of motion, grip force, and compatibility with your labware.
**Accessories and modules.** Confirm which accessories are included: barcode readers, tip counters, heating/cooling modules, shakers, and integrated instruments vary by configuration.
**Software and licensing.** Control software, method files, and licenses vary by platform and may require transfer or repurchase. Confirm software version compatibility with your operating system and any integrated instruments.
**Computer and controller.** Some systems include a dedicated controller PC. Confirm OS version, hardware compatibility, and whether the controller is included.
**Service history.** Where available, request service records, PM documentation, and any calibration or qualification records. Not all used systems will have complete documentation.
**Calibration and qualification.** Regulated laboratories should plan for IQ/OQ/PQ upon installation. mLab Supply does not guarantee that every system has been calibrated or qualified to a specific standard prior to sale.
**Included labware carriers.** Confirm which plate carriers, tube carriers, tip racks, and reservoirs are included with the system.
---
## Software, Methods, and Integration
Software and licensing are critical considerations when purchasing a used automated liquid handler.
**Control software.** Each platform uses proprietary control software (e.g., Biomek Software, Hamilton Run Control, EVOware, epBlue, VWorks). Confirm the software version included with the system and whether it is compatible with your operating system.
**Method files.** Existing method files may be transferable with the system, but compatibility with your specific configuration and software version should be verified.
**Licensing.** Software licenses vary by platform. Some licenses are tied to the instrument serial number; others require separate purchase or transfer. Confirm licensing terms before purchase.
**Computer compatibility.** Some systems require a specific controller PC or OS version. Confirm hardware and OS requirements for the software version included.
**LIMS integration.** Many platforms support LIMS connectivity via barcode scanning, file-based data exchange, or direct API integration. Integration requirements vary by LIMS and platform.
**Scheduling software.** Workcell configurations may require scheduling software (e.g., Momentum, SAMI, Overlord) in addition to the liquid handler control software. Confirm whether scheduling software is included and licensed.
**Buyer IT requirements.** Confirm network connectivity requirements, firewall rules, and IT security policies before installation, particularly for systems that connect to LIMS or scheduling platforms.
Software and license availability vary by system and configuration. Contact mLab Supply to confirm what is included with a specific listing.
---
## Applications
Automated liquid handlers support a broad range of laboratory workflows:
- **PCR and qPCR setup** — Accurate, reproducible reaction assembly at scale
- **NGS library preparation** — End repair, adapter ligation, size selection support, and normalization
- **ELISA and immunoassay plate setup** — Consistent reagent addition and sample dilution
- **Sample normalization** — DNA, RNA, and protein concentration normalization across plates
- **Serial dilution** — Compound dose-response curves and standard curve preparation
- **Plate replication** — High-fidelity plate copying and reformatting
- **Compound handling** — Compound management, cherry picking, and library reformatting
- **Assay development** — Rapid protocol iteration and optimization
- **Genomics and proteomics** — Sample preparation for sequencing, mass spectrometry, and array workflows
- **Drug discovery** — High-throughput screening support, hit confirmation, and SAR follow-up
- **High-throughput screening** — Plate-based assay setup at scale
Suitability for a specific application depends on the system configuration, software, and accessories. Contact mLab Supply to discuss your workflow requirements.
---
## Throughput and Workflow Planning
Effective use of an automated liquid handler requires planning beyond the instrument itself.
**Plates per run and per day.** Estimate your target plate output and confirm that the system deck capacity, tip consumption, and reagent reservoir volume support your run size without operator intervention.
**Unattended operation.** Systems with plate hotels, tip stacks, and scheduling software can run extended unattended batches. Confirm hotel capacity and tip stack depth for your target run length.
**Deck layout.** Plan deck positions for tips, reagents, source plates, destination plates, and waste. Confirm that your workflow fits within the available deck footprint.
**Reagent reservoirs.** Confirm reservoir volume and format compatibility. Some workflows require temperature-controlled reagent positions.
**Tip consumption.** Estimate tip usage per run and confirm that tip rack capacity and restocking frequency are compatible with your throughput targets.
**Integration with readers, washers, and sealers.** Workcell configurations that include plate readers, washers, or heat sealers require compatible integration hardware and scheduling software. Confirm integration requirements before purchase.
**Operator intervention.** Even highly automated systems may require periodic operator intervention for tip restocking, reagent replenishment, or plate loading. Plan staffing accordingly.
---
## Procurement and Logistics
mLab Supply supports formal B2B procurement workflows for laboratory equipment acquisition.
**Formal quotations.** Submit a quote request through our [Request a Quote](/pages/request-a-quote) page. We will confirm availability, configuration, pricing, and lead time within 1–2 business days.
**Purchase orders.** We accept purchase orders from qualified institutions. Net 30 terms are available for approved accounts.
**Vendor onboarding.** We can support vendor registration and onboarding processes for universities, hospitals, and corporate procurement teams.
**Sourcing specific configurations.** If you require a specific model, configuration, or accessory set not currently listed, contact us. We actively source equipment to match buyer requirements.
**Freight and rigging.** Large liquid handling workstations may require specialized freight, rigging, or liftgate service. We coordinate freight logistics and can advise on installation site requirements.
**Deinstallation.** For systems being relocated from another facility, we can advise on deinstallation requirements and coordinate logistics where applicable.
**Installation planning.** We can provide guidance on site preparation, power requirements, and installation planning for select systems.
**Surplus equipment purchasing.** If your laboratory has surplus liquid handling equipment to sell, visit our [Sell Lab Equipment](/pages/sell-lab-equipment) page or contact us directly.
---
## Related Laboratory Equipment
mLab Supply sources a broad range of laboratory automation and life science instruments. Related equipment categories include:
- [Microplate Readers](/collections/microplate-readers) — Absorbance, fluorescence, and luminescence detection for plate-based assays
- [Microplate Washers](/collections/microplate-washers) — Automated plate washing for ELISA and cell-based assays
- [Thermal Cyclers](/collections/thermal-cyclers) — PCR and gradient cycling for nucleic acid amplification
- [qPCR Systems](/collections/qpcr-systems) — Real-time quantitative PCR for gene expression and copy number analysis
- [Beckman Coulter Laboratory Equipment](/collections/beckman-coulter) — Full Beckman Coulter instrument catalog
- [Agilent Technologies Laboratory Equipment](/collections/agilent-technologies) — Full Agilent instrument catalog
- [Request a Quote](/pages/request-a-quote) — Submit a sourcing request for any system
- [Sell Lab Equipment](/pages/sell-lab-equipment) — Trade in or sell surplus laboratory instruments
---
## Frequently Asked Questions
<div class="mlab-collection-faq">
<details>
<summary>What is an automated liquid handler?</summary>
An automated liquid handler is a laboratory instrument that performs precise, programmable liquid transfers — including aspiration, dispensing, dilution, and plate reformatting — without manual pipetting. These systems range from compact benchtop units for routine sample prep to full-deck robotic workstations for high-throughput screening and genomics workflows.
</details>
<details>
<summary>What workflows are automated liquid handlers used for?</summary>
Common applications include NGS library preparation, PCR and qPCR setup, ELISA plate setup, sample normalization, serial dilution, compound management, plate replication, and high-throughput screening support. Specific workflow suitability depends on the system configuration, software, and accessories.
</details>
<details>
<summary>How do Beckman Biomek, Hamilton STAR, Tecan EVO, Agilent Bravo, and Eppendorf epMotion systems differ?</summary>
Each platform has distinct strengths. Beckman Biomek systems offer a broad range of configurations from compact benchtop units to high-throughput full-deck workstations. The Hamilton Microlab STAR is widely used in genomics and clinical automation for its precision and modular architecture. Tecan Freedom EVO systems are frequently configured as workcell hubs with broad integration support. The Agilent Bravo is optimized for plate-based NGS library prep and compound reformatting. The Eppendorf epMotion 5075 is a compact benchtop system suited for PCR setup and routine normalization. Contact mLab Supply to discuss which platform best fits your workflow.
</details>
<details>
<summary>What volume range should I consider?</summary>
Volume range depends on your assay requirements. Most air-displacement platforms operate from approximately 0.5–1 µL to 1,000 µL per channel, though specific ranges vary by head configuration and tip type. Acoustic systems such as the Beckman Echo operate in the nanoliter range. Confirm the volume range of any system against your assay specifications before purchase.
</details>
<details>
<summary>What should I inspect before buying a used automated liquid handler?</summary>
Key inspection points include pipetting head condition and accuracy, deck alignment and labware carrier fit, liquid-level sensing function, gripper range of motion, tip compatibility, included accessories and modules, software version and licensing, controller PC condition, and available service history. mLab Supply can provide available documentation for specific listings.
</details>
<details>
<summary>Are tips and labware carriers included with used systems?</summary>
Included accessories vary by listing. Some systems are sold with tip racks, labware carriers, and reservoirs; others are sold as instrument-only. Contact mLab Supply to confirm what is included with a specific system before submitting a quote request.
</details>
<details>
<summary>Is software included with used liquid handlers?</summary>
Software and licensing availability vary by platform and listing. Control software, method files, and licenses may or may not be transferable. Some licenses are tied to the instrument serial number and require vendor involvement to transfer. Confirm software and licensing details with mLab Supply before purchase.
</details>
<details>
<summary>Can mLab Supply source a specific configuration or model?</summary>
Yes. If a specific model, configuration, or accessory set is not currently listed, submit a quote request and we will actively source it. We work with a broad network of laboratory equipment suppliers and can often locate specific configurations on request.
</details>
<details>
<summary>Are refurbished liquid handlers suitable for regulated laboratories?</summary>
Used and refurbished liquid handlers can be used in regulated environments (GMP, GLP, CAP, CLIA), but suitability depends on the specific system, its condition, and your regulatory requirements. Regulated laboratories should plan for IQ/OQ/PQ validation upon installation. mLab Supply does not guarantee that systems have been pre-qualified to any specific regulatory standard. Consult your quality and compliance team before purchase.
</details>
<details>
<summary>Does mLab Supply coordinate freight and installation planning?</summary>
Yes. Large liquid handling workstations may require specialized freight, rigging, or liftgate service. mLab Supply can coordinate freight logistics and advise on site preparation and installation planning for select systems. Contact us when requesting a quote to discuss logistics requirements.
</details>
<details>
<summary>Does mLab Supply buy surplus liquid handling systems?</summary>
Yes. If your laboratory has surplus automated liquid handlers or other laboratory equipment to sell, visit our <a href="/pages/sell-lab-equipment">Sell Lab Equipment</a> page or contact us directly. We purchase individual instruments and full laboratory lots.
</details>
</div>
Selecting the right liquid handling workstation depends on your workflow requirements, throughput targets, and laboratory infrastructure. Key factors to evaluate:
**Throughput and run volume.** Estimate your daily plate output and whether you need unattended overnight operation. High-throughput screening labs typically require 96- or 384-channel heads and integrated plate hotels, while lower-throughput genomics workflows may be well served by an 8-channel or span-8 system.
**Deck capacity.** Count the number of deck positions required for tips, reagent reservoirs, labware carriers, and integrated instruments. Larger decks support more complex workflows but require more bench space.
**Pipetting volume range.** Confirm the minimum and maximum aspiration volumes for your assay. NGS library prep and low-volume compound handling require accurate sub-microliter dispensing; ELISA and normalization workflows typically operate in the 10–200 µL range.
**Channel count and head configuration.** Single-channel, 8-channel, 96-channel, and span-8 heads each offer different throughput and flexibility trade-offs. Some platforms support interchangeable heads.
**Disposable tips vs. fixed tips.** Disposable tip systems reduce cross-contamination risk and are standard for most life science workflows. Fixed-tip systems (common in acoustic and some positive-displacement platforms) require wash steps between transfers.
**Labware compatibility.** Verify that the system supports your plate formats, tube types, and reservoir configurations. Confirm tip compatibility with your preferred tip vendor.
**Grippers and plate movement.** Integrated gripper arms allow automated plate transport between deck positions and integrated instruments. Confirm gripper reach and compatibility with your labware stack heights.
**Onboard accessories.** Barcode readers, tip counters, liquid-level sensing, and integrated shakers or heating/cooling modules vary by platform and configuration.
**Scheduling software and integration.** Evaluate the method development environment, scripting complexity, and compatibility with your LIMS, scheduling software, and any integrated instruments such as plate readers, centrifuges, or sealers.
**Footprint and serviceability.** Confirm bench dimensions and weight capacity. Consider local service availability and spare parts access for the platform you select.
---
## Automated Liquid Handler Types
### Air-Displacement Pipetting Workstations
Air-displacement systems are the most common platform in life science laboratories. They use a sealed air column to aspirate and dispense liquid, with disposable tips to prevent cross-contamination. Platforms such as the Beckman Coulter Biomek series, Hamilton Microlab STAR, Tecan Freedom EVO, and Eppendorf epMotion use air-displacement pipetting. These systems are well suited for genomics, proteomics, ELISA, normalization, and general sample preparation.
### Positive-Displacement / Specialized Pipetting
Positive-displacement systems use a piston in direct contact with the liquid, making them suitable for viscous, volatile, or high-density samples where air-displacement accuracy is compromised. Some platforms offer positive-displacement heads as optional accessories.
### Acoustic Liquid Handling
Acoustic liquid handlers use focused sound energy to transfer nanoliter-to-microliter volumes without tips, eliminating tip costs and cross-contamination risk. The Beckman Coulter Echo 525 and Echo 650 are acoustic platforms commonly used for compound management, assay miniaturization, and DMSO-based transfers. Acoustic systems are not suitable for all liquid types and require compatible source plate formats.
### Integrated Robotic Workstations
Some liquid handling platforms are designed as the central component of a larger robotic workcell, with robotic arms, plate hotels, incubators, readers, and sealers integrated around a central scheduler. The Hamilton STAR and Tecan Freedom EVO are frequently configured as workcell hubs. These systems offer the highest throughput and automation depth but require more complex method development and infrastructure.
---
## Popular Manufacturers and Platforms
<div class="mlab-collection-model-grid">
**Beckman Coulter**
- Biomek FXᴾ — Full-deck, 96/384-channel capable workstation for high-throughput genomics and screening
- Biomek NXᴾ — Flexible benchtop platform with span-8 and 96-channel head options
- Biomek 4000 — Mid-range workstation with modular deck and multi-channel pipetting
- Biomek i3 — Compact intelligent workstation for routine sample prep
- Biomek i5 — Mid-range intelligent workstation with expanded deck capacity
- Biomek i7 — High-capacity intelligent workstation for complex, high-throughput workflows
- Echo 525 — Acoustic liquid handler for nanoliter compound and assay transfers
- Echo 650 — Higher-throughput acoustic platform with expanded source plate capacity
**Hamilton**
- Microlab STAR — Modular, high-precision workstation widely used in genomics, NGS prep, and clinical automation
**Tecan**
- Freedom EVO — Configurable workcell platform with broad labware and integration support
- Freedom EVO 150 — Compact EVO variant with 150 mm deck width for space-constrained environments
**Eppendorf**
- epMotion 5075 — Compact benchtop liquid handler for PCR setup, normalization, and routine sample prep
**Agilent Technologies**
- Bravo — Plate-based liquid handling platform commonly used for NGS library prep and compound reformatting
</div>
---
## Automated Liquid Handlers vs Manual Pipetting
Automated liquid handlers and manual pipetting each have a role in laboratory workflows. The right choice depends on throughput, reproducibility requirements, budget, and assay complexity.
**Throughput.** Manual pipetting is practical for low-volume, low-frequency tasks. Automated systems become cost-effective when processing dozens to hundreds of plates per week, or when run frequency justifies the capital investment.
**Reproducibility.** Automated systems eliminate operator-to-operator variability in pipetting volume, timing, and technique. This is particularly important for quantitative assays, NGS library preparation, and regulated workflows where inter-operator variability must be controlled.
**Operator variability and ergonomics.** Repetitive manual pipetting carries ergonomic risk. Automation reduces operator fatigue and the associated variability in high-volume workflows.
**Method setup.** Automated systems require upfront method development and validation. Simple workflows can be programmed quickly on most platforms; complex multi-step protocols require more development time.
**Flexibility.** Manual pipetting is more flexible for ad hoc, low-volume, or highly variable tasks. Automated systems are optimized for defined, repeatable workflows.
**Capital cost.** Automated liquid handlers represent a significant capital investment. Used and refurbished systems can substantially reduce acquisition cost while delivering the same workflow capability.
**Validation burden.** Regulated laboratories (GMP, GLP, CAP, CLIA) must validate automated liquid handling systems before use. Validation requirements vary by regulatory framework and intended use.
---
## Buying Used and Refurbished Liquid Handlers
Used and refurbished automated liquid handlers can deliver significant cost savings compared to new systems. When evaluating a pre-owned system, consider the following:
**Pipetting head condition.** Inspect or request documentation on pipetting accuracy and precision. Tip eject function, seal integrity, and piston condition affect pipetting performance.
**Deck alignment.** Confirm that deck positions are correctly calibrated and that labware carriers seat properly. Misalignment can cause tip pickup failures and liquid transfer errors.
**Liquid-level sensing.** Many platforms include capacitive or pressure-based liquid-level sensing. Confirm that sensing hardware is present and functional if required for your workflow.
**Tip compatibility.** Verify that the system is compatible with your preferred tip vendor and that tip adapters or racks are included or available.
**Gripper function.** If the system includes a gripper arm, confirm range of motion, grip force, and compatibility with your labware.
**Accessories and modules.** Confirm which accessories are included: barcode readers, tip counters, heating/cooling modules, shakers, and integrated instruments vary by configuration.
**Software and licensing.** Control software, method files, and licenses vary by platform and may require transfer or repurchase. Confirm software version compatibility with your operating system and any integrated instruments.
**Computer and controller.** Some systems include a dedicated controller PC. Confirm OS version, hardware compatibility, and whether the controller is included.
**Service history.** Where available, request service records, PM documentation, and any calibration or qualification records. Not all used systems will have complete documentation.
**Calibration and qualification.** Regulated laboratories should plan for IQ/OQ/PQ upon installation. mLab Supply does not guarantee that every system has been calibrated or qualified to a specific standard prior to sale.
**Included labware carriers.** Confirm which plate carriers, tube carriers, tip racks, and reservoirs are included with the system.
---
## Software, Methods, and Integration
Software and licensing are critical considerations when purchasing a used automated liquid handler.
**Control software.** Each platform uses proprietary control software (e.g., Biomek Software, Hamilton Run Control, EVOware, epBlue, VWorks). Confirm the software version included with the system and whether it is compatible with your operating system.
**Method files.** Existing method files may be transferable with the system, but compatibility with your specific configuration and software version should be verified.
**Licensing.** Software licenses vary by platform. Some licenses are tied to the instrument serial number; others require separate purchase or transfer. Confirm licensing terms before purchase.
**Computer compatibility.** Some systems require a specific controller PC or OS version. Confirm hardware and OS requirements for the software version included.
**LIMS integration.** Many platforms support LIMS connectivity via barcode scanning, file-based data exchange, or direct API integration. Integration requirements vary by LIMS and platform.
**Scheduling software.** Workcell configurations may require scheduling software (e.g., Momentum, SAMI, Overlord) in addition to the liquid handler control software. Confirm whether scheduling software is included and licensed.
**Buyer IT requirements.** Confirm network connectivity requirements, firewall rules, and IT security policies before installation, particularly for systems that connect to LIMS or scheduling platforms.
Software and license availability vary by system and configuration. Contact mLab Supply to confirm what is included with a specific listing.
---
## Applications
Automated liquid handlers support a broad range of laboratory workflows:
- **PCR and qPCR setup** — Accurate, reproducible reaction assembly at scale
- **NGS library preparation** — End repair, adapter ligation, size selection support, and normalization
- **ELISA and immunoassay plate setup** — Consistent reagent addition and sample dilution
- **Sample normalization** — DNA, RNA, and protein concentration normalization across plates
- **Serial dilution** — Compound dose-response curves and standard curve preparation
- **Plate replication** — High-fidelity plate copying and reformatting
- **Compound handling** — Compound management, cherry picking, and library reformatting
- **Assay development** — Rapid protocol iteration and optimization
- **Genomics and proteomics** — Sample preparation for sequencing, mass spectrometry, and array workflows
- **Drug discovery** — High-throughput screening support, hit confirmation, and SAR follow-up
- **High-throughput screening** — Plate-based assay setup at scale
Suitability for a specific application depends on the system configuration, software, and accessories. Contact mLab Supply to discuss your workflow requirements.
---
## Throughput and Workflow Planning
Effective use of an automated liquid handler requires planning beyond the instrument itself.
**Plates per run and per day.** Estimate your target plate output and confirm that the system deck capacity, tip consumption, and reagent reservoir volume support your run size without operator intervention.
**Unattended operation.** Systems with plate hotels, tip stacks, and scheduling software can run extended unattended batches. Confirm hotel capacity and tip stack depth for your target run length.
**Deck layout.** Plan deck positions for tips, reagents, source plates, destination plates, and waste. Confirm that your workflow fits within the available deck footprint.
**Reagent reservoirs.** Confirm reservoir volume and format compatibility. Some workflows require temperature-controlled reagent positions.
**Tip consumption.** Estimate tip usage per run and confirm that tip rack capacity and restocking frequency are compatible with your throughput targets.
**Integration with readers, washers, and sealers.** Workcell configurations that include plate readers, washers, or heat sealers require compatible integration hardware and scheduling software. Confirm integration requirements before purchase.
**Operator intervention.** Even highly automated systems may require periodic operator intervention for tip restocking, reagent replenishment, or plate loading. Plan staffing accordingly.
---
## Procurement and Logistics
mLab Supply supports formal B2B procurement workflows for laboratory equipment acquisition.
**Formal quotations.** Submit a quote request through our [Request a Quote](/pages/request-a-quote) page. We will confirm availability, configuration, pricing, and lead time within 1–2 business days.
**Purchase orders.** We accept purchase orders from qualified institutions. Net 30 terms are available for approved accounts.
**Vendor onboarding.** We can support vendor registration and onboarding processes for universities, hospitals, and corporate procurement teams.
**Sourcing specific configurations.** If you require a specific model, configuration, or accessory set not currently listed, contact us. We actively source equipment to match buyer requirements.
**Freight and rigging.** Large liquid handling workstations may require specialized freight, rigging, or liftgate service. We coordinate freight logistics and can advise on installation site requirements.
**Deinstallation.** For systems being relocated from another facility, we can advise on deinstallation requirements and coordinate logistics where applicable.
**Installation planning.** We can provide guidance on site preparation, power requirements, and installation planning for select systems.
**Surplus equipment purchasing.** If your laboratory has surplus liquid handling equipment to sell, visit our [Sell Lab Equipment](/pages/sell-lab-equipment) page or contact us directly.
---
## Related Laboratory Equipment
mLab Supply sources a broad range of laboratory automation and life science instruments. Related equipment categories include:
- [Microplate Readers](/collections/microplate-readers) — Absorbance, fluorescence, and luminescence detection for plate-based assays
- [Microplate Washers](/collections/microplate-washers) — Automated plate washing for ELISA and cell-based assays
- [Thermal Cyclers](/collections/thermal-cyclers) — PCR and gradient cycling for nucleic acid amplification
- [qPCR Systems](/collections/qpcr-systems) — Real-time quantitative PCR for gene expression and copy number analysis
- [Beckman Coulter Laboratory Equipment](/collections/beckman-coulter) — Full Beckman Coulter instrument catalog
- [Agilent Technologies Laboratory Equipment](/collections/agilent-technologies) — Full Agilent instrument catalog
- [Request a Quote](/pages/request-a-quote) — Submit a sourcing request for any system
- [Sell Lab Equipment](/pages/sell-lab-equipment) — Trade in or sell surplus laboratory instruments
---
## Frequently Asked Questions
<div class="mlab-collection-faq">
<details>
<summary>What is an automated liquid handler?</summary>
An automated liquid handler is a laboratory instrument that performs precise, programmable liquid transfers — including aspiration, dispensing, dilution, and plate reformatting — without manual pipetting. These systems range from compact benchtop units for routine sample prep to full-deck robotic workstations for high-throughput screening and genomics workflows.
</details>
<details>
<summary>What workflows are automated liquid handlers used for?</summary>
Common applications include NGS library preparation, PCR and qPCR setup, ELISA plate setup, sample normalization, serial dilution, compound management, plate replication, and high-throughput screening support. Specific workflow suitability depends on the system configuration, software, and accessories.
</details>
<details>
<summary>How do Beckman Biomek, Hamilton STAR, Tecan EVO, Agilent Bravo, and Eppendorf epMotion systems differ?</summary>
Each platform has distinct strengths. Beckman Biomek systems offer a broad range of configurations from compact benchtop units to high-throughput full-deck workstations. The Hamilton Microlab STAR is widely used in genomics and clinical automation for its precision and modular architecture. Tecan Freedom EVO systems are frequently configured as workcell hubs with broad integration support. The Agilent Bravo is optimized for plate-based NGS library prep and compound reformatting. The Eppendorf epMotion 5075 is a compact benchtop system suited for PCR setup and routine normalization. Contact mLab Supply to discuss which platform best fits your workflow.
</details>
<details>
<summary>What volume range should I consider?</summary>
Volume range depends on your assay requirements. Most air-displacement platforms operate from approximately 0.5–1 µL to 1,000 µL per channel, though specific ranges vary by head configuration and tip type. Acoustic systems such as the Beckman Echo operate in the nanoliter range. Confirm the volume range of any system against your assay specifications before purchase.
</details>
<details>
<summary>What should I inspect before buying a used automated liquid handler?</summary>
Key inspection points include pipetting head condition and accuracy, deck alignment and labware carrier fit, liquid-level sensing function, gripper range of motion, tip compatibility, included accessories and modules, software version and licensing, controller PC condition, and available service history. mLab Supply can provide available documentation for specific listings.
</details>
<details>
<summary>Are tips and labware carriers included with used systems?</summary>
Included accessories vary by listing. Some systems are sold with tip racks, labware carriers, and reservoirs; others are sold as instrument-only. Contact mLab Supply to confirm what is included with a specific system before submitting a quote request.
</details>
<details>
<summary>Is software included with used liquid handlers?</summary>
Software and licensing availability vary by platform and listing. Control software, method files, and licenses may or may not be transferable. Some licenses are tied to the instrument serial number and require vendor involvement to transfer. Confirm software and licensing details with mLab Supply before purchase.
</details>
<details>
<summary>Can mLab Supply source a specific configuration or model?</summary>
Yes. If a specific model, configuration, or accessory set is not currently listed, submit a quote request and we will actively source it. We work with a broad network of laboratory equipment suppliers and can often locate specific configurations on request.
</details>
<details>
<summary>Are refurbished liquid handlers suitable for regulated laboratories?</summary>
Used and refurbished liquid handlers can be used in regulated environments (GMP, GLP, CAP, CLIA), but suitability depends on the specific system, its condition, and your regulatory requirements. Regulated laboratories should plan for IQ/OQ/PQ validation upon installation. mLab Supply does not guarantee that systems have been pre-qualified to any specific regulatory standard. Consult your quality and compliance team before purchase.
</details>
<details>
<summary>Does mLab Supply coordinate freight and installation planning?</summary>
Yes. Large liquid handling workstations may require specialized freight, rigging, or liftgate service. mLab Supply can coordinate freight logistics and advise on site preparation and installation planning for select systems. Contact us when requesting a quote to discuss logistics requirements.
</details>
<details>
<summary>Does mLab Supply buy surplus liquid handling systems?</summary>
Yes. If your laboratory has surplus automated liquid handlers or other laboratory equipment to sell, visit our <a href="/pages/sell-lab-equipment">Sell Lab Equipment</a> page or contact us directly. We purchase individual instruments and full laboratory lots.
</details>
</div>